Ruth R Wexler Selected Research

Factor XIa (Coagulation Factor XIa)

1/2022	Milvexian, an orally bioavailable, small-molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits.
1/2020	Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
1/2020	Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
2/2014	Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Ruth R Wexler Research Topics

Disease

17	Thrombosis (Thrombus) 01/2022 - 12/2002
12	Hemorrhage 01/2020 - 12/2002
5	Heart Failure 10/2022 - 01/2020
5	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 12/2018
2	Atherosclerosis 11/2020 - 11/2017
2	Inflammation (Inflammations) 01/2019 - 12/2018
2	Atrial Fibrillation 11/2017 - 07/2014
2	Carotid Artery Thrombosis 08/2007 - 12/2002
1	Animal Disease Models 06/2022
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021
1	Atherosclerotic Plaque (Atheroma) 01/2019
1	Chronic Disease (Chronic Diseases) 11/2017
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 07/2007

Drug/Important Bio-Agent (IBA)

5	AnticoagulantsIBA 01/2020 - 12/2002
4	Clopidogrel (Plavix)FDA Link 01/2022 - 08/2007
4	Factor XIa (Coagulation Factor XIa)IBA 01/2022 - 02/2014
4	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2020 - 12/2002
4	Factor VIIa (Activated Factor VII)IBA 01/2017 - 02/2014
3	Apelin ReceptorsIBA 10/2022 - 01/2021
3	EnzymesIBA 01/2022 - 01/2020
3	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022 - 11/2013
2	compound 21IBA 12/2021 - 01/2016
2	Peroxidase (Myeloperoxidase)IBA 01/2021 - 11/2017
2	pyridineIBA 01/2020 - 11/2017
2	Lipase (Acid Lipase)FDA Link 10/2019 - 12/2018
2	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 08/2006
2	Thromboplastin (Tissue Factor)IBA 11/2016 - 02/2014
2	Factor Xa (Coagulation Factor Xa)IBA 09/2011 - 12/2003
2	apixabanIBA 09/2011 - 05/2008
2	Factor Xa InhibitorsIBA 08/2007 - 12/2002
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 06/2022
1	milvexianIBA 01/2022
1	apelin-13 peptideIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 11/2020
1	Peptides (Polypeptides)IBA 01/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	ApelinIBA 01/2020
1	HDL CholesterolIBA 01/2020
1	BenzothiazolesIBA 10/2019
1	CholesterolIBA 01/2019
1	HDL LipoproteinsIBA 01/2019
1	protease-activated receptor 4IBA 01/2019
1	Sulfides (Thioethers)IBA 12/2018
1	SulfonamidesIBA 11/2017
1	QuinazolinesIBA 11/2017
1	Pharmaceutical PreparationsIBA 01/2017
1	AntibodiesIBA 01/2017
1	BMS-986120IBA 01/2017
1	Serine Proteases (Serine Protease)IBA 12/2016
1	Prasugrel Hydrochloride FDA Link 07/2014
1	Potassium Channels (Potassium Channel)IBA 07/2014
1	Purinergic P2Y1 ReceptorsIBA 06/2014
1	Purinergic P2Y Receptor AntagonistsIBA 06/2014
1	BMS 593214IBA 04/2013
1	anthranilamideIBA 05/2008
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/2007
1	razaxabanIBA 08/2007
1	Gamma Secretase Inhibitors and ModulatorsIBA 07/2007
1	Blood Coagulation Factors (Coagulation Factor)IBA 08/2006
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 12/2002
1	1- (3- (aminomethyl)phenyl)- N- (3- fluoro- 2'- (methylsulfonyl)(1,1'- biphenyl)- 4- yl)- 3- (trifluoromethyl)- 1H- pyrazole- 5- carboxamideIBA 12/2002
1	argatroban (MPQA)FDA Link 12/2002
1	pyrazoleIBA 12/2002
1	Enoxaparin (Lovenox)FDA LinkGeneric 12/2002
1	Thrombin FDA Link 12/2002

Therapy/Procedure

2	Therapeutics 01/2020 - 08/2007
1	Intravenous Administration 12/2017